Fluconazole is a very selective inhibitor of fungal cytochrome P450 dependent enzyme lanosterol 14-α-demethylase. This enzyme normally works to convert lanosterol to ergosterol, which is necessary for fungal cell wall synthesis. The free nitrogen atom located on the azole ring of fluconazole binds with a single iron atom located in the heme group of lanosterol 14-α-demethylas
Fluconazole can be administered in the treatment of the following fungal infections, This medication can be used to treat oral thrush, which is a fungal infection in the mouth and throat.
Fluconazole is also used to treat Candida infections of the esophagus, which can occur in immunocompromised individuals, In some cases, fluconazole 200 mg might be used to treat skin infections caused by dermatophytes, although other antifungals are often preferred for these types of infection